FA Cup replays will be abolished after the first round of the 2024-25 season.
All rounds of the Emirates FA Cup will also be held over the weekend, including the fifth round, which has been held in midweek for the past five seasons.
The changes were made as part of a new six-year agreement between the Football Association (FA) and the Premier League.
The Premier League has also removed the mid-season break from its calendar.
Games are due to start in mid-August after a three-week summer break, rather than a short winter break, and the decision will be based on “expert advice from the medical and technical departments”.
Under the current system, there are no rematches in the FA Cup after the fifth round, but the FA is moving to eliminate rematches from an earlier stage “taking into account changes to the calendar due to the expansion of UEFA competitions”. It is said that
UEFA will launch the European Conference League in 2021, and the number of teams in next season’s Champions League group stage will increase from 32 to 36. FIFA has announced that the number of teams participating in the Club World Cup to be held in 2025 will be expanded to 32 teams.
Replays will continue in the FA Cup qualifying rounds, where teams from the fifth to tenth divisions of English football compete for the 32 spots in the first round.
The first round of the FA Cup will feature professional teams from League One and League Two, with teams from the Championship League and Premier League taking part in the third round.
Other changes mean that the fourth and fifth rounds, as well as the quarter-finals, will be played without Premier League fixtures for the first time.
The fourth round will be played in an extended period from Friday to Wednesday.
The FA Cup final has also been moved to the penultimate weekend of the Premier League season.
It will be held on a Saturday and is separate from the Premier League fixtures, with the Friday before the final also being held “to allow us to focus on preparations for the high-profile event”.
The deal will also see the Premier League increase its funding for grassroots football, with an additional £33m available.
FA CEO Mark Bullingham said: “The FA Cup is our greatest asset.”
“This new agreement between the FA and the Premier League will strengthen the FA Cup and give this very special tournament an exclusive weekend in an increasingly busy calendar.
“We have also agreed new funding for grassroots games, disability football and women’s games.
“All football starts at the grassroots and this is recognized by the Premier League and any additional financial support is very welcome.”